TB-500
Proper Handling
- Directions: Reconstitute with 2 mL (200 Units) of Bacteriostatic Water prior to use.
- Specifications: Lyophilized powder in 3 mL vial. Purity (>99%) meets or exceeds U.S. Pharmacopeia (USP) and National Formulary (USP-NF) regulations.
- Storage: In lyophilized form, the peptide is stable for 3 years. Protect from light. Refrigerate and use within 6 weeks after opening or reconstituting.
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TB-500 is a synthetic peptide of a protein that all humans have in their bodies. The natural protein occurs in cells and is called Thymosin Beta 4. This protein may have healing properties.
TB-500 may help speed up injury recovery. Some injuries and wounds could take several months or longer to heal on their own, TB-500 peptide may reduce that time.
CAS Number 885340-08-9
PubChem CID 62707662
Molecular Weight 889.0 g/mol
Molecular Formula C38H68N10O14
Synonyms TB500; TB 500; TB-500; L-Glutamine
Storage (Lyophilized)
At 39 Fahrenheit: 2 years
At -4 Fahrenheit: 3 years
is for research purposes only, unless prescribed by a licensed physician. Schedule a telehealth appointment to determine the best plan for your health. This product comes in the form of lyophilized powder and must be reconstituted with bacteriostatic water prior to use. Please refer to our terms and conditions prior to purchase.
Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.
The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.
- Kleinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.
- Julia Parmley, A Life-Saving Discovery, January 04, 2010.
- Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039. PMID: 18480812.
- Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.
- Katherine M. Malinda et.al, Thymosin β4 Accelerates Wound Healing, Journal of Investigative Dermatology, Volume 113, Issue 3, 1999, Pages 364-368, ISSN 0022-202X.
- Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012 Oct.
- Wei C, Kim IK, Li L, Wu L, Gupta S. Thymosin Beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. PLoS One. 2014 Nov 20;9(11):e110598.
- Gao, Xy., Hou, F., Zhang, Zp. et al. Role of thymosin beta 4 in hair growth. Mol Genet Genomics 291, 1639–1646 (2016).
- Esposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Analysis. 2012 Sep.
- Piao Z, Hong CS, Jung MR, Choi C, Park YK. Thymosin β4 induces invasion and migration of human colorectal cancer cells through the ILK/AKT/β-catenin signaling pathway. Biochem Biophys Res Commun. 2014 Sep 26;452(3):858-64.
- Study of Thymosin Beta 4 in Patients with Pressure Ulcers https://www.clinicaltrials.gov/ct2/show/NCT00382174
- A Phase 2 study of the effect of Thymosin Beta 4 on Wound Healing in Patients https://www.clinicaltrials.gov/ct2/show/NCT00311766
Frequently Asked Questions
TB-500
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TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide present in the body. It is known for its role in promoting healing, reducing inflammation, and enhancing recovery, particularly in soft tissues like muscles, tendons, and ligaments. TB-500 is widely used in sports medicine, rehabilitation, and anti-aging therapies due to its ability to support tissue repair and regeneration.
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Tissue Repair and Regeneration
Accelerated Healing: TB-500 is well-known for its ability to accelerate the healing of injuries, particularly those involving tendons, ligaments, and muscles. It helps reduce the time needed for recovery, making it a valuable tool for athletes and individuals recovering from surgeries or injuries.
Wound Healing: The peptide promotes the migration of cells to injury sites, facilitating faster and more efficient wound healing. This is especially beneficial for chronic wounds or areas where healing is typically slow.
Anti-Inflammatory Effects
Reduction in Inflammation: TB-500 has potent anti-inflammatory properties, which can help reduce pain and swelling associated with acute injuries or chronic conditions such as arthritis. By modulating the body’s inflammatory response, it aids in quicker recovery and pain relief.
Improved Flexibility and Mobility
Enhanced Muscle Tone: TB-500 can improve muscle tone and flexibility by reducing muscle stiffness and promoting healthy muscle tissue. This is particularly beneficial for individuals with muscle tightness, spasms, or those recovering from muscle injuries.
Joint and Ligament Health: The peptide also supports joint and ligament health, making it easier to maintain or regain mobility after an injury or surgery.
Cardiovascular and Blood Vessel Support
Angiogenesis: TB-500 promotes the formation of new blood vessels (angiogenesis), which can improve blood flow to tissues, aiding in the delivery of nutrients and oxygen necessary for healing.
Heart Health: There is emerging evidence suggesting TB-500 may have protective effects on the heart, particularly in promoting repair after cardiac injury.
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TB-500 is an injectable peptide administered subcutaneously through the fat. The most fatty parts of the body are the abdomen, side or back of upper arms, and front of thighs.
This peptide is for research purposes only, unless prescribed by a licensed physician.
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Clinical Applications
- Sports Medicine and Rehabilitation: TB-500 is commonly used in sports medicine for its ability to speed up recovery from injuries, reduce inflammation, and enhance tissue repair. It is particularly valuable for athletes and active individuals who need to return to their activities quickly.
- IV Therapy: While TB-500 is often administered via subcutaneous injection, it has also be integrated into IV therapy protocols, especially in combination with other supportive treatments. IV clinics might offer TB-500 in cycles, with treatment durations tailored to individual patient needs.
- Wound Care: The peptide can be a part of treatment protocols for chronic wounds, post-surgical healing, and other conditions where tissue regeneration is necessary. Its role in promoting cell migration and angiogenesis makes it a powerful tool in wound care.
- Anti-Aging Therapy: Due to its regenerative properties, TB-500 is also used in anti-aging therapies to support overall tissue health and reduce the impact of aging on the musculoskeletal system.
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In the case of TB-500, the side effects appear to be mild. The most common side effects include:
- face flushing
- possible headache
- dizziness
- lethargy
The boost to the immune system may have some contraindications for people with auto-immune diseases, such as psoriasis, Hashimoto’s, and rheumatoid arthritis.
Remember, everyone reacts differently to substances like TB-500 due to individual physiological differences such as metabolism rate and overall health status. Consult with a licensed healthcare professional if you are considering peptide therapy.
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Cancer or Tumor History
Growth Promotion: TB-500 may promote cellular growth and migration, which could be problematic in individuals with active cancer or a history of cancer. This peptide is generally contraindicated in these cases.
Autoimmune Disorders
Immune System Modulation: Although TB-500 is known for its anti-inflammatory effects, individuals with autoimmune disorders, such as psoriasis, Hashimoto’s, and rheumatoid arthritis, should use it cautiously. There is a potential risk of altering the immune response, which may exacerbate autoimmune conditions.
Severe Acute Infections
Infection Risk: Since TB-500 can influence cell migration and immune responses, it should be used with caution in patients with severe or acute infections. The peptide may affect the body’s ability to manage infections effectively.
Hypersensitivity
Allergic Reactions: Patients with known hypersensitivity to any component of the peptide formulation should not use TB-500.
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We're happy to help answer questions you may have, or refer you to a licensed healthcare professional for medical advice. Email us at care@somapeptides.com or schedule a telehealth appointment.
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